Documents › Publications · Last reviewed 2026-05-16
Original publications
Summary
Chronological list of the main peer-reviewed publications of the VUmc / Amsterdam UMC research team and their international collaborators on the Dutch Protocol. PubMed identifiers (PMID) are listed where available. For each study a separate dossier page is available under /studies/.
1998–2009
- Cohen-Kettenis PT, van Goozen SHM. Pubertal delay as an aid in diagnosis and treatment of a transsexual adolescent. Eur Child Adolesc Psychiatry. 1998;7(4):246–8. PMID: 9879847. → /studies/cohen-kettenis-1998/
- Cohen-Kettenis PT, van Goozen SHM. Sex reassignment of adolescent transsexuals: a follow-up study. J Am Acad Child Adolesc Psychiatry. 1997;36(2):263–71.
- Delemarre-van de Waal HA, Cohen-Kettenis PT. Clinical management of gender identity disorder in adolescents. Eur J Endocrinol. 2006;155(S1):S131–7. → /studies/delemarre-2006/
- Cohen-Kettenis PT, Delemarre-van de Waal HA, Gooren LJ. The treatment of adolescent transsexuals: changing insights. J Sex Med. 2008;5(8):1892–7.
2010–2019
- de Vries ALC, Noens ILJ, Cohen-Kettenis PT, et al. Autism spectrum disorders in gender dysphoric children and adolescents. J Autism Dev Disord. 2010;40(8):930–6. → /protocol/exclusion-criteria/
- de Vries ALC, Steensma TD, Doreleijers TAH, Cohen-Kettenis PT. Puberty suppression in adolescents with gender identity disorder: a prospective follow-up study. J Sex Med. 2011;8(8):2276–83. → /studies/de-vries-2011/
- de Vries ALC, McGuire JK, Steensma TD, et al. Young adult psychological outcome after puberty suppression and gender reassignment. Pediatrics. 2014;134(4):696–704. → /studies/de-vries-2014/
- Steensma TD, McGuire JK, Kreukels BPC, et al. Factors associated with desistence and persistence of childhood gender dysphoria. J Am Acad Child Adolesc Psychiatry. 2013;52(6):582–90. → /studies/steensma-2013-desistance/
2020–present
- Brik T, et al. Trajectories of adolescents treated with gonadotropin-releasing hormone analogues. Arch Sex Behav. 2020;49(7):2611–8.
- van der Loos MATC, et al. Continuation of gender-affirming hormones in adolescents and young adults. Lancet Child Adolesc Health. 2022;6(12):869–75. → /studies/follow-up-studies-overview/
- van der Loos MATC, et al. Bone mineral density in transgender adolescents treated with puberty suppression. JAMA Pediatr. 2023.
PubMed search strategy
A current search in PubMed: ("Dutch Protocol"[tiab] OR "puberty suppression"[tiab] OR (GnRH AND adolescent AND gender)) AND (Cohen-Kettenis OR de Vries OR Delemarre).
See also
- People register — Cohen-Kettenis, Delemarre, de Vries, Steensma, van der Loos.
- Timeline — publications in chronological context.
- Studies — overview — dossier pages per publication with summary and criticism.
- Follow-up studies — overview — all later cohort publications.
- Methodological criticism — overarching methodological concerns.
- Replication attempts — international attempts to replicate the Dutch results.
- Guidelines international — how these publications are embedded internationally.
- FAQ · Glossary · For clinicians.